Amgen reported 8% revenue growth and 14% non-GAAP EPS growth in the third quarter. Management raised full-year guidance for both measures, with the revenue midpoint up $500 million to $39.3 billion and the non-GAAP EPS midpoint up $0.40 to $23.30. Shares fell 2% after hours on Nov. 3.
Amgen's cholesterol drug Repatha revived our enthusiasm for the firm's research engine, and Blincyto (blood cancer) and Tezspire (asthma) also look differentiated.
Bears
Biosimilars have been on the market in Europe since 2007 but have had a larger impact on Amgen since 2019 as US exposure intensifies. Pressure on Prolia/Xgeva intensified in 2026.
Amgen is a leader in biotechnology-based human therapeutics. Flagship drugs include red blood cell boosters Epogen and Aranesp, immune system boosters Neupogen and Neulasta, and Enbrel and Otezla for inflammatory diseases. Amgen introduced its first cancer therapeutic, Vectibix, in 2006 and markets bone-strengthening drugs Prolia/Xgeva (approved 2010) and Evenity (2019). The acquisition of Onyx Pharmaceuticals bolstered the firm's therapeutic oncology portfolio with Kyprolis, which has been further strengthened with the launch of new drugs in blood cancers (Blincyto) and solid tumors (Imdelltra). The 2023 Horizon acquisition brought several rare-disease drugs, including thyroid eye disease drug Tepezza. Amgen also has a growing biosimilar portfolio.