Merck's first-quarter revenue grew 5% to reach $16.3 billion, with a non-GAAP loss of $1.28 per share after incorporating the cost of the Cidara acquisition. Shares fell roughly 2% on April 30.
Keytruda's leadership position in the immuno-oncology landscape, buoyed by a first-mover advantage in first-line non-small cell lung cancer, could become even further entrenched as Merck and other firms test new combinations with the drug.
Bears
The US patent loss on Keytruda in 2028 is concerning, given the high sales contribution of the drug (46% of 2024 sales).
Merck makes pharmaceutical products to treat several conditions in a number of therapeutic areas, including cardiometabolic disease, cancer, and infections. Within cancer, the firm's immuno-oncology platform, led by Keytruda, is a major contributor to overall sales. The company also has a substantial vaccine business aimed at preventing pediatric diseases, as well as Gardasil for human papillomavirus. Additionally, Merck sells animal health-related drugs. From a geographical perspective, 47% of the company's sales are generated from US human health (pharmaceuticals and vaccines).