Pfizer: Competitive Advantages Still Exist, but Signs of Erosion Lead Us to Lower Our Valuation
We’ve also reduced the firm’s moat rating from wide to narrow.

Key Morningstar Metrics for Pfizer
- Fair Value Estimate: $38.00
- Morningstar Rating: ★★★★★
- Morningstar Economic Moat Rating: Narrow
- Morningstar Uncertainty Rating: Medium
Pfizer PFE faces patent expirations amounting to more than one quarter of 2024 revenue by 2028, and the 2023 acquisition of oncology-focused biotech Seagen boosted the firm’s invested capital base, lowering adjusted returns on invested capital to 7.3% in 2024.
Why it matters: We estimate Pfizer’s cost of capital at 7.1%, and our projected high-single-digit ROICs do not provide much of a buffer against potential emerging headwinds to profitability over the next decade.
- Blockbuster products like cancer drug Ibrance and cardiovascular drugs Eliquis and Vyndaqel will likely face generic competition in 2027-28, adding pressure on Pfizer’s pipeline.
- We think the fate of Seagen’s pipeline programs and the relative positioning of its antibody-drug conjugate technology will be key in determining Pfizer’s pipeline productivity.
The bottom line: We’re lowering our fair value estimate for Pfizer to $38 per share from $42 after reducing the firm’s moat rating from wide to narrow, accounting for the thin margin of our ROIC forecast over its cost of capital.
- We also factored pressure from the Donald Trump administration into our tax rate forecast (rising to 19% in the long run with increased US manufacturing) and moat rating. While we see most favored nation pricing as unlikely, Pfizer has less of a ROIC buffer than its peers to handle pressure to US profits.
- Our $7.7 billion 2030 forecast for revenue from the Seagen portfolio is still below management’s $10 billion goal, although we’re carefully watching Padcev’s expansion into new indications and advancement of the phase 3 pipeline.
Big picture: We think Pfizer shares still look significantly undervalued, as despite flat growth prospects, its 7% dividend yield and the steadiness of its diversified portfolio are compelling.
Editor’s Note: This analysis was originally published as a stock note by Morningstar Equity Research.
The author or authors do not own shares in any securities mentioned in this article. Find out about Morningstar’s editorial policies.
