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Novartis Says Pelacarsen Heart Disease Drug Missed Primary Endpoint

Provided by Dow Jones Sep 4, 2026, 8:57:00 PM

By Elias Schisgall

Novartis said a heart disease drug did not meet its primary endpoint in a Phase 3 study.

The company on Friday said that the drug, pelacarsen, did not reduce the risk of cardiovascular events--including deaths, heart attacks, and strokes--compared to a placebo.

The drug did succeed in lowering lipoprotein(a) levels, Novartis said.

"These are not the results we hoped for, but they provide important evidence that advances scientific understanding of the relationship between Lp(a) lowering and cardiovascular outcomes and may help inform future approaches to cardiovascular risk management," Chief Medical Officer Shreeram Aradhye said.

Shares declined 4.4% to $153.00 in after-hours trading on Friday.

Write to Elias Schisgall at elias.schisgall@wsj.com

(END) Dow Jones Newswires

September 04, 2026 16:57 ET (20:57 GMT)

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