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Takeda Ends Denali Therapeutics Dementia-Drug Partnership

Provided by Dow Jones Apr 3, 2026, 6:04:00 PM

By Katherine Hamilton

Denali Therapeutics said Takeda Pharmaceuticals terminated the companies' agreement to co-develop and commercialize a dementia drug.

Denali would regain full ownership of DNL593, an investigational drug designed to treat frontotemporal dementia-granulin.

In 2018, Denali and Takeda entered into an option and collaboration agreement to develop and commercialize up to three specified therapeutic product candidates for neurodegenerative diseases.

Denali said it plans to report results from the continuing Phase 1/2 trial of DNL593 by the end of this year.

Write to Katherine Hamilton at katherine.hamilton@wsj.com

(END) Dow Jones Newswires

April 03, 2026 14:04 ET (18:04 GMT)

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