4D Molecular Shares Rise Premarket on Partnership With Otsuka

By Colin Kellaher


Shares of 4D Molecular Therapeutics moved higher in premarket trading Friday after the biotechnology company said it formed a partnership potentially worth hundreds of millions of dollars with Japan's Otsuka Pharmaceutical.

4D late Thursday said it will grant Otsuka exclusive rights to develop and commercialize its 4D-150 drug candidate for retinal vascular diseases, including wet age-related macular degeneration and diabetic macular edema, in Japan, China, Australia and other Asia-Pacific markets.

4D said it will receive an $85 million upfront cash payment from Otsuka and expects to receive at least $50 million of cost sharing from its partner over the next three years for development activities supporting global registration.

The Emeryville, Calif., company said it is also eligible to receive up to $336 million in regulatory and commercial milestone payments, along with royalties on product sales.

4D shares, which closed Thursday at $11.32, were recently up 10% to $12.49 in premarket trading.


Write to Colin Kellaher at colin.kellaher@wsj.com


(END) Dow Jones Newswires

October 31, 2025 07:14 ET (11:14 GMT)

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