Ionis Pharmaceuticals Inc

IONS: XNAS (USA)

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Ionis Earnings: Near-Term Tryngolza Launch Challenges Obscure Long-Term Earnings Power

Rachel Elfman

Nov 10, 2026

Ionis reported third-quarter revenue of $243 million, up 55% year over year. While management reaffirmed 2026 revenue, operating loss, and cash guidance, it cut 2026 Tryngolza (for sHTG/FCS) revenue guidance by 50% to approximately $50 million, triggering a 21% decline in the shares on Nov. 9.

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Ionis Pharmaceuticals Inc

Ionis Earnings: Near-Term Tryngolza Launch Challenges Obscure Long-Term Earnings Power

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