Ionis Pharmaceuticals Inc

IONS: XNAS (USA)

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Ionis Earnings: Early Signs of Commercial Momentum for Tryngolza as Key Catalysts Approach

Rachel Elfman

Jul 31, 2026

Ionis posted revenue of $268 million in the second quarter, up 56% year over year, excluding last year's one-time sapablursen upfront payment. Ionis maintained its 2026 guidance of roughly $890 million of revenue at the midpoint, including Tryngolza (olezarsen) net product sales of $105 million.

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Ionis Pharmaceuticals Inc

Ionis Earnings: Early Signs of Commercial Momentum for Tryngolza as Key Catalysts Approach

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