Ionis Pharmaceuticals Inc

IONS: XNAS (USA)

Morningstar Rating for Stocks	Fair Value	Economic Moat	Capital Allocation
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Ionis Earnings: Strong Revenue Growth Reflects Solid Commercial Execution Capabilities

Rachel Elfman

Feb 27, 2026

Ionis generated $944 million in 2025 revenue, up 34% year over year, driven in part by $108 million in first-year sales of Tryngolza (for familial chylomicronemia syndrome). Despite strong top-line growth, Ionis ended the year with an adjusted operating loss of $248 million.

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Ionis Pharmaceuticals Inc

Ionis Earnings: Strong Revenue Growth Reflects Solid Commercial Execution Capabilities

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