Alnylam Pharmaceuticals Inc

ALNY: XNAS (USA)

Morningstar Rating for Stocks	Fair Value	Economic Moat	Capital Allocation
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Alnylam: US Approval of Amvuttra in ATTR-CM Significantly Expands Addressable Patient Population

Rachel Elfman , Rashmi Nair

Mar 21, 2025

Narrow-moat Alnylam Pharmaceuticals has received US Food and Drug Administration approval for Amvuttra (vutrisiran), the first RNAi therapeutic for adults with ATTR amyloidosis with cardiomyopathy, or ATTR-CM. The shares were up about 11% in March 21 trading. We have adjusted our model to account for the approval (our base case was previously a 95% probability of approval), and we maintain our $223 fair value estimate.

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Alnylam Pharmaceuticals Inc

Alnylam: US Approval of Amvuttra in ATTR-CM Significantly Expands Addressable Patient Population

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