Popular Articles From: Merck Announces Positive Study Investigating the Use of KEYTRUDA® (pembrolizumab) Compared to Chemotherapy in Patients with Ipilimumab-Refractory Advanced Melanoma to Molina Healthcare Reports Third Quarter 2014 Results


Merck (NYSE:MRK), known as MSD outside the United States and Canada, announced today that a pre-specified analysis of investigational data from a pivotal Phase 2 study (KEYNOTE-002) showed KEYTRUDA® (pembrolizumab), the company’s anti-PD-1 therapy, substantially improved the primary endpoint of progression-free survival (PFS, as assessed by RECIST 1.1, independent central review) (HR 0.57 and 0.50 for 2 mg/kg and 10 mg/kg every three week doses, respectively), compared to chemotherapy (P<0.0001 for both comparisons) in patients with ipilimumab-refractory advanced melanoma (n=540). At six months, the PFS rates for KEYTRUDA were 34 percent at the 2 mg/kg dose (95% CI, 27-41) (n=180) and 38 percent at the 10 mg/kg dose (95% CI, 31-45) (n=181), compared to 16 percent for chemotherapy (95% CI, 10-22) (n=179). The median duration of follow-up at the interim analysis was 10 months.
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Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced that new data from clinical studies of the company’s investigational, oral, once-daily, fixed-dose combination chronic hepatitis C treatment grazoprevir/elbasvir (MK-5172/MK-8742) are scheduled to be presented at the 65 th American Association for the Study of Liver Diseases (AASLD) Annual Meeting, also known as The Liver Meeting ® .
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2014/12/1
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By Michael Wursthorn Bank of America Corp.'s wealth-management unit has lost a 33-year veteran.
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Micro Focus (LSE: MCRO.L) today announced a series of Developer Days across North America designed to showcase the critical role that COBOL systems play within the enterprise, and how organizations can harness their existing mainframe, Windows, Unix and Linux-based COBOL business systems to support new technologies including mobile, cloud, .NET and JVM.
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Molina Healthcare, Inc. (NYSE: MOH): Net income per diluted share, continuing operations, of $0.33, doubles 2013 results of $0.16. Adjusted net income per diluted share, continuing operations 1 , of $0.83 increases 17% over 2013 results of $0.71. Membership surpasses 2.4 million.
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Popular Articles From: Merck Announces Positive Study Investigating the Use of KEYTRUDA® (pembrolizumab) Compared to Chemotherapy in Patients with Ipilimumab-Refractory Advanced Melanoma to Molina Healthcare Reports Third Quarter 2014 Results
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